2021-04-04
https://www.iltalehti.fi/politiikka/a/0df6edf3-cd47-487f-92f3-be878a3d629a Kuinka pitkä on Gene Simmonsin kieli? Muista ottaa meidän
The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. Methods: After the lentiviral CD47-siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit-8, and the apoptosis of stem cells of acute myeloid leukemia was detected by … Gene information about ENSG00000196776 / CD47 - CD47 molecule. Gene name. Class 2020-12-01 Transcriptional control of the CD47 gene is incompletely understood and has only been studied in the context of neuronal development, where transcription of CD47 and concomitant neurite outgrowth relies on the transcription factor α-Pal/NRF-1 (Chang and Huang, 2004; Chang et al., 2005). Gene ontology; Molecular function CD47 has a single Ig-like extracellular domain and five membrane spanning regions.
Human CD47-related genes are present in many Poxviridae including Vaccinia virus CD47 (AAB96477), variola virus CD47 (P33853) and Yaba monkey tumor virus (AB025319). A phylogenetic tree analysis indicated viral CD47 divergence occurred before the divergence of rodents and primates (Hughes 2002). They inserted the CD47 gene into a virus, which was transduced into human and mouse stem cells with no MHC proteins. When these stem cells were transplanted into mismatched mice with normal mice immune systems as well as humanized mouse immune systems, there was no observed rejection. CD47 is similar to these genes: Galectin-3, Dermatopontin, BCAR1 and more. Human Gene CD47 (uc003dwt.1) Description and Page Index Description: Homo sapiens CD47 molecule (CD47), transcript variant 1, mRNA. RefSeq Summary (NM_001777): This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix.
Genome editing or gene 1 Oct 2018 CD47 has been found to be present on leukemic stem cells, but not on normal hematopoietic stem cells, offering an opportunity to target the The MIAP301 monoclonal antibody reacts with mouse CD47 otherwise known as integrin-associated protein (IAP). CD47 is an approximately 50 kDa Irv Weissman discovered that pediatric brain tumor, leukemia, bone tumor and neuroblastoma cells overproduce a cell surface protein known as CD47. The 2 Nov 2018 CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia.
CD47 is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The protein is also a receptor for the
Mice were subjected to 90 min middle cerebral artery occlusion. CD47 knockout mi … By blocking CD47-mediated signaling with antibodies in mice infected with lymphocytic choriomeningitis virus, the authors demonstrated they could enhance the speed of pathogen clearance. Furthermore, knocking out the CD47 gene in mice improved their ability to control M. tuberculosis infections and significantly prolonged their survival.
The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The gene is 87,896 bases in length [citation needed]. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons. Function
Gene: Cd47 - ENSMUSG00000055447 - Mus musculus (mouse) General information. Ensembl ID: ENSMUSG00000055447: Name: Cd47: Description Description: Homo sapiens CD47 molecule (CD47), transcript variant 1, mRNA. (from RefSeq NM_001777) RefSeq Summary (NM_001777): This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. Functional Associations. CD47 has 6,184 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 79 datasets. CD47 is a cell surface glycoprotein that helps mediate neutrophil transmigration across blood vessels. The present study was performed to determine whether absence of the CD47 gene decreases focal ischemic brain damage.
CD47 antigen (Rh-related antigen, integrin-associated signal transducer) Synonyms. 9130415E20Rik, B430305P08Rik
The gene view histogram is a graphical view of mutations across CD47_ENST00000355354. These mutations are displayed at the amino acid level across the full length of the gene by default.
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Gene ontology; Molecular function CD47 has a single Ig-like extracellular domain and five membrane spanning regions. The interaction between SIRPα and CD47 can be modified by endocytosis or cleavage of the receptor, or interaction with surfactant proteins. Cd47: Description: CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [Source:MGI Symbol;Acc:MGI:96617] Organism: Mus musculus: Synonym(s) 9130415e20rik, aa407862, ai848868, … Believing that CD47 might hold the key to completely shutting down rejection, the researchers loaded the CD47 gene into a virus, which delivered extra copies of the gene into mouse and human stem cells in which the MHC proteins had been knocked out. CD47 indeed proved to … CD47: Description: CD47 molecule [Source:HGNC Symbol;Acc:HGNC:1682] Organism: Homo sapiens: Synonym(s) a8k198, d3dn59, iap, mer6, oa3, q53y71, q96a60: Orthologs(s) 17 orthologs 2021-01-14 This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene.
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2 Nov 2018 CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin's Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia. 7 Mar 2013 The passport is based on a protein found on nearly all mammalian cell membranes, CD47, which is known as a marker of "self." While the
Dr Naval Daver speaks to ecancer in an online interview for the virtual EHA 2020 meeting. He describes the background, study design and results of this. 29 Nov 2017 When CD47 binds to a protein called SIRPalpha on the surface of macrophages, a “don't eat me” signal is triggered and the macrophage ignores
CD47 (Cluster of Differentiation 47) also known as integrin associated protein ( IAP) is a transmembrane protein that in humans is encoded by the CD47 gene.
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Abstract. Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRPα and
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